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KMID : 0043319970200020148
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Archives of Pharmacal Research
1997 Volume.20 No. 2 p.148 ~ p.154
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Chlorogenic Acid, an Antioxidant Principle from the Aerial Parts of Artemisia iwayomogi that Acts on 1,1-Diphenyl-2-picrylhydrazyl Radical
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Kim Soon-Shin
Lee Chung-Gyu
Kang Sam-Sik
Jung Hyun-Ah
Choi Jae-Sue
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Abstract
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The antioxidant activity of Artemisia iwayomogi was determined by measuring the radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. The methanol extract of A. iwayomogi showed strong antioxidant activity, and thus fractionated with several solvents. The antioxidant activity potential of the individual fraction was in the order of ethyl acetate > n-butanol > water > chloroform > n-hexane fraction. The ethyl acetate and n-butanol soluble fractions exhibiting strong antioxidant activity were further purified by repeated sitica get and Sephadex LH-20 column chromatography. Antioxidant chlorogenic acid was isolated as one of the active principles from the n-butanol fraction, together with the inactive components, 1octacosanol, scopoletin, scopolin, apigenin -di-O-methylether, luteolin -di-O-methylether (jaceosidin), apigenin methylether (genkwanin), 2, 4-dihydroxy-6-methoxyacetophenone D-glucopyranoside and quebrachitol. The antioxidant activity of chlorogenic acid was comparable to that of L-ascorbic acid, which is a well known antioxidant.
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KEYWORD
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Artemisia iwayomogi, chlorogenic acid, antioxidant activity, 1-octacosanol, apigenin 7.4′-di-O-methylether, jaceosidin, genkwanin, 2, 4-dihydroxy-6-methoxyacetophenone 4-Q-β-D-glucopyranoside
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